・He took the trouble to come and see me.＝He went to the trouble of coming and seeing me.＝He went to a lot of [considerable, much] trouble to come and see me. 彼はわざわざ私に会いに来てくれた.

b 苦心, 骨折り, 苦労 (exertion, pains); 困難, 苦労 (difficulty).

・take trouble with [over, about] one's work＝take trouble to work [working] 骨を惜しまず仕事をする.

・give oneself (the) trouble 骨折る, 尽力する.

・have a lot of trouble to keep [keeping] out of debt 借金をしまいと大いに苦心する.